Telomere dysfunction is now known to be one of the causes of aging. Within the skin, increasing amounts of evidence are linking telomere ‘attrition’ (shortening) to skin aging, but more research is needed to demonstrate the direct link between telomerase and improved skin health. Namely, extending their health and the function of the skin, more than just acting as a cosmetic (improving only the appearance, focusing on the surface) while we target aging at the molecular level. What is Skinspan? And that’s where we come in. We believe that your aesthetic age is an investment, worth your hard earned dollars. But you have to be smart about it! We help you do just that. The hardest one, I would say, is trying to manage stress. Running a company is sometimes very challenging.

LB:And to that point, the name of your company is actually based on some science, you've got this number in there - “ 818”. There's a fascinating scientific story behind where that number comes from. Could you tell us about that? CR: OneSkin is a longevity company. The fundamental approach of our technology is to understand aging and to develop interventions that can target and reverse aging. You use a topical supplement in the same way that you take a supplement to improve your organs, internally. But a topical supplement treats our largest organ – the skin. By treating your skin topically (“on top of”) with this supplement, you optimize the health of the skin. RD: I do encourage twice daily use, as all of our experiments are done on twice daily use. The more frequently you activate telomerase, the better results.He was very enthused to try out OneSkin OS-01 using the above framework, where he applied OS-01 daily to a clean face before bedtime with approximately 98% compliance over 5 months. If the product really can reduce your skin’s biological age, then you might just make this investment. RD: All of that was done by Dr. Bill Andrews, before we even popped TAM 818 into a skin cream. He was able to say, on his scale of measurement, that TAM 818 was a 16% “HeLa”. LB: That's a grand vision and will get our readers very excited. You just talked about skin aging, hair loss, fat tissue, and these being driven by cellular senescence. This all fits into a bigger picture for longevity technologies over the next decade and more.

More important than looking younger, however, is the need to reverse or delay the age related decline in the health of your skin, becoming known as your skinspan (the healthspan of your skin). CR: Aging happens at the molecular level. As we age, we observe many mechanisms in the body that stopworking properly. One clear example is the accumulation of DNA mutations, which in the skin are primarily caused by sun damage. Prior to the Visia scan, I had actually run a 6 week retinol experiment on the skin surrounding my eyes. Maybe that has already led to me appearing younger than my 34 years, given I look 31!Give us some advice on how our readers can run a self experiment and come to the conclusion - yes, OS-01 helped my skin be healthier. Here are two areas of action I will be experimenting with improve my aesthetic age before my next Visia scan. UV Damage